Urocortin
نویسندگان
چکیده
منابع مشابه
Urocortin Expression in Endometriosis: A Systematic Review
Urocortin is a neuropeptide belonging to the corticotrophin-releasing hormone family and is expressed by eutopic and ectopic human endometrium and the last years is investigated in the field of endometriosis. The objective of this systematic review is to accumulate current evidence related to the expression of urocortin in tissue and blood samples of patients suffering from endometriosis. Liter...
متن کاملUrocortin 2 and urocortin 3 in endometriosis: evidence for a possible role in inflammatory response.
Urocortin 2 (Ucn 2) and urocortin 3 (Ucn 3) are neuropeptides expressed by human endometrium. This study evaluated (i) the expression of Ucn 2 and Ucn 3 mRNA in endometriotic lesions and in endometrium of women with endometriosis; (ii) the effect of Ucn 2 and Ucn 3 on cytokines secretion from cultured endometrial stromal cells. Endometriotic tissue was collected from endometrioma (n=39); endome...
متن کاملUrocortin Immediate and Sustained Blood Pressure Lowering by Urocortin 2 A Novel Approach to Antihypertensive Therapy?
Recently, novel corticotropin-releasing factor-related peptides, named urocortin 1, 2, and 3, and a distinct cardiac and peripheral vascular receptor (corticotropin-releasing factor receptor 2) were described being part of a peripheral corticotropin-releasing factor system modulating cardiovascular function in response to stress. Vasorelaxation and blood pressure lowering have been reported aft...
متن کاملCardiovascular effects of urocortin 2 and urocortin 3 in patients with chronic heart failure
AIMS Urocortin 2 and urocortin 3 may play a role in the pathophysiology of heart failure and are emerging therapeutic targets. We aimed to examine the local and systemic cardiovascular effects of urocortin 2 and urocortin 3 in healthy subjects and patients with heart failure. METHODS Patients with heart failure (n = 8) and age and gender-matched healthy subjects (n = 8) underwent bilateral fo...
متن کاملUrocortin 2 infusion in human heart failure.
AIMS To document the haemodynamic, neurohormonal, and renal responses to Urocortin 2 (UCN2) infused in human heart failure (HF). METHODS AND RESULTS Eight male patients with HF [left ventricular ejection fraction (LVEF) < 40%, NYHA class II-III] received placebo and 25 [low dose (LD)] and 100 microg [high dose (HD)] of UCN2 intravenously over 1 h in a single-blind, placebo-controlled, dose-es...
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ژورنال
عنوان ژورنال: Circulation
سال: 2005
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.105.584441